Metabolism Matters – the Role of Glutamate/glutamine Metabolism in Brain Function and Disease


Tarrytown House Estate on the Hudson
49 East Sunnyside Lane.
Tarrytown, NY 10591
(800) 553-8118 or (914) 591-8200


Thursday, November 10, 2016
Date & Time Event
6:00PM-7:00PM Welcome Reception, Library/Sunporch
7:00PM-9:00PM Dinner, Library/Sunporch

Testimonial 1: Mary McKenna
Testimonial 2: Richard Hawkins (video)
Friday, November 11, 2016
Date & Time Event
7:30AM-8:45AM Breakfast in the Mansion
  Symposium Events, New York Room
8:50AM-9:10AM Opening Remarks


Beta-Methylene Aspartate and Me and Arthur Makes Three
Susan M. Fitzpatrick, James S. McDonnell Foundation
9:15AM-10:30AM Session 1: Glutamate and GABA neurotransmitter and nitrogen cycles – linking brain metabolism, and function
  9:15-9:25 Chair: Doug Rothman and Gerry Dienel
  9:25-9:50 Kevin Behar, The glutamate/GABA-glutamine cycle and functional neuroenergetics
  10:00-10:25 Mary McKenna, Glutamate dehydrogenase (GDH) and aspartate aminotransferase (AAT) -- key enzymes that integrate glutamate metabolism with energy metabolism
10:30AM-11:00AM Break
11:00AM-12:15PM Session 2:     Glutamate/glutamine metabolism and  neurological disease
  11:00-11:10 Chair: Andreas Plaitakis and Martyn Sharpe
  11:10-11:35 Roger Butterworth, “Caught in traffic? Inter-cellular glutamine metabolism and encephalopathy”.
  11:40-12:10 Charlotte Stagg, In vivo MRS studies of brain glutamate/glutamine metabolism in brain plasticity and neurological recovery
12:15PM-1:30PM Session 3: Brain mitochondrial energetics and neurological disease
  12:15-12:25 Chair: Jim Lai and Flint Beal
  12:25-12:50 Emile Van Schaftingen, Diseases of metabolic repair
  12:55-1:20 Gary Gibson, “Why is the alpha Ketoglutarate dehydrogenase complex is so critical in Alzheimer’s Disease?”
1:30PM-2:15PM Lunch: Stories from Arthur Cooper's past (Open microphone), Library/Sunporch
2:15PM-3:30PM Session 4: Glutaminases in neurodegenerative diseases and cancer
  2:15-2:25 Chair: Mary Anderson and Susan Browne
  2:25-2:50 Tom Jeitner, Transglutaminases in Neurodegeneration
  2:55-3:20 Richard Cerione, Glutamine Metabolism in Cancer Cell Metabolism and Treatment
3:30PM-4:00PM Closing Remarks: Arthur Cooper
4:00PM-5:00PM Reception, Library/Sunporch