Food for Thought: The Ketogenic Diet and Neurological Diseases

Tarrytown House Estate on the Hudson
49 East Sunnyside Lane.
Tarrytown, NY 10591
USA
(800) 553-8118 or (914) 591-8200
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Thursday, November 2, 2017

Date & Time	Event
6:00PM-7:00PM	Welcome Reception, Library/Sunporch
7:00PM-9:00PM	Dinner, Library/Sunporch

Friday, November 3, 2017

Date & Time	Event
7:30AM-8:45AM	Breakfast in the Mansion

	Symposium Events, Henry Hudson Room

8:50AM-10:45AM	Session 1: Ketogenesis in Context
		Chair: Suzana Herculano Houzel
	8:50-9:20	Kevin Behar - General physiological effects of ketogenesis: The effects of ketogenesis on human physiology. Ketone metabolism in the human brain; knowns and unknowns. Summary of brain ketone metabolism in studies of subjects without brain diseases. Species and developmental age differences. What neurological functions can and cannot be supported by ketones?
	9:20-9:35	Questions & Discussion
	9:35-10:05	Adam Hartman - Identifying the key metabolic characteristics of ketogenic diets: Ketogenesis? Calorie restriction? Energy restriction? Anti-inflammation? Something else? All these and more?
	10:05-10:20	Questions & Discussion
	10:20-10:45	General Discussion

10:45AM-11:00AM	Break

11:05AM-1:05PM	Session 2: Ketogenic diets and epilepsy
		Chair: Hannah Landecker
	11:05-11:35	Susan Masino - Historical overview of the use of Ketogenic diets in pediatric epilepsy and the proposed mechanisms for its clinical effectiveness.
	11:35-11:50	Questions & Discussion
	11:50-12:20	Jong Rho - Learning from failures: When ketogenic diets are ineffective in epilepsy or other seizure disorders do we know why? What have we learned from other neurological disorder case studies? What characterizes the key components of the KD required for clinical efficacy in different patient groups?
	12:20-12:35	Questions & Discussion
	12:35-1:00	General Discussion

1:15PM-2:45PM	Lunch in the Mansion

2:50PM-4:50PM	Session 3: Ketogenic diets in neurological diseases other than epilepsy – what’s the rationale?
	The focus for this session will be on neurodegenerative disease and brain tumor – two case studies that should generalize to other neurological disorders. The important questions include: What is the rationale for thinking the KD would be effective in neurodegenerative disorders? The KD has been considered for Alzheimer’s, Parkinson’s, and ALS. How useful will it be in diseases where cell loss is a major component of the pathophysiology? There is some evidence that the KD can be effective in brain tumor patients – what mechanistic knowledge is available? Where do we have data from humans? Is possible to learn anything from individuals self-initiating the diet as a treatment?
		Chair: Peter Canoll
	2:50-3:10	Discussant 1: Karin Borges
	3:10-3:30	Discussant 2: Adrienne Scheck
	3:30-4:50	Group Discussion

6:00PM-7:00PM	Reception

7:00PM-9:00PM	Dinner in the Mansion

Saturday, November 4, 2017

Date & Time	Event
7:30AM-8:45AM	Breakfast in the Mansion

	Workshop, Henry Hudson Room

8:50AM-10:45AM	Session 4: Ketogenic diets – opportunities for mechanistic studies in human patients
	The interest in using the KD clinically is high. This presents the opportunity to prospectively design optimal clinical studies. What would be the right patient group to target? Ideally, what data should be acquired? What is the best use of existing and emerging technologies? Ideas that might be tested: Can the brain adapt (or develop resistance?) to chronic use of KD? Does intermittent non-compliance contribute to failure or could intermittence be useful if constrained by mechanism?
		Chair: John Laterra
	8:50-9:10	Discussant 1: Eric Kossoff
	9:10-9:30	Discussant 2: Srishti Nangia
	9:30-10:45	Group Discussion

10:45AM-11:05AM	Break

11:05AM-1:05PM	Final Session
	Recommendations for progress based on cumulative suggestions made during the workshop.
		Chair: Susan Fitzpatrick
	11:05-11:20	Presenter 1: Henk de Feyter
	11:20-11:35	Presenter 2: Farah Lubin
	11:35-1:05	Group Discussion & Recommendations

1:15PM-2:45PM	Lunch in the Mansion & Departures

Food for Thought: The Ketogenic Diet and Neurological Diseases

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