Begins: 6:30 PM, Wednesday,
November 2nd
Ends: 12:30 PM, Friday, November 4th
49 E. Sunnyside Lane
Tarrytown, NY 10591
US
https://www.tarrytownhouseestate.com/
| Date & Time | Event | |
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| 6:30PM-7:30PM | Opening Reception, Library/Sunporch Room | |
| 7:30PM-9:30PM | Dinner, Library/Sunporch Room Welcome & Introductions Framing talk by Susan Fitzpatrick and Doug Rothman Please note – the opening dinner is not optional but is an important and central component of the workshop. Our long experience with workshops indicates that participants who miss the opening dinner fail to fully benefit from the discussions. During dinner there will be brief introductions. A brief summary of the prior workshops and the ideas that began to emerge that led to several observations that could be telling us something important: the efficacy of “dirty” treatments versus precision treatments, so-called paradoxical findings (e.g. the arousing effect of benzodiazepines on a subset of TBI patients) indicating our lack of circuit level understanding, and the need for a complex view of genes x experience x environment interactions that takes life span neurodevelopmental trajectories seriously. The idea that emerged was to use an intensive “case study” look at a serious and often clinically intractable neuropsychiatric disorder – schizophrenia – as an impetus for creating a new framework with the potential to inform research and clinical practice and contribute to better care and improved lives. |
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| Date & Time | Event | |
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| 7:00AM-8:30AM | Breakfast in the Mansion | |
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Workshop, New York Room |
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| 9:00AM | Meeting Begins | |
| Session One - Chair, Michael Halassa |
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| 9:10AM-9:30AM | Framing the task: scientific and clinical
context Michael Halassa This talk will help frame what can be expected to come out of the discussions. The expertise of everyone in the room is related to cognitive processing, a defining feature of the human condition and the feature most impacted by serious neuropsychiatric illnesses such as schizophrenia – this workshop hopes to integrate across areas of expertise to emerge with an integrated framework for what it is that is “disordered” in neuropsychiatric disorders. |
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| 9:35AM-10:05AM | An observational portrait of clinical
schizophrenia Don Goff and Dost Ongur In this talk Don and Dost will provide their joint observations describing as much as is known about the clinical picture of individuals with serious schizophrenia. The difficult task for these two speakers is represent a somewhat agnostic observational overview rather than couching the clinical observations in the reigning theories about the disorder. Age of onset characteristics? What is known about triggering events? What do patients have in common? How do they depart from one another? What characterizes high functioning individuals? The idea here is to really frame – in the most agnostic way – what it is exactly that research and clinical medicine is trying to deal with stripped of the limiting pre-conceptions. It may be useful for all workshop participants to be considering the following questions:
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| 10:05AM-10:25AM | Short break | |
| 10:30AM | Session One Continues - Chair, John Laterra | |
| 10:30AM-11:00AM | From neuropharmacology to computational
psychiatry Michael J. Frank To a large extent the neuropharmacology of schizophrenia has been over simplified. How can we integrate neuropharmacology with circuitry and an understanding of function that can give a more sophisticated approach to treatment that acknowledges the roots of the disorder are not neurotransmitter “imbalances”? |
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| 11:05AM-11:35AM | Schizophrenia from a cognitive/behavioral
perspective Philippa Garety The challenge for this speaker is to expand our understanding of cognitive behavioural accounts of what is disordered in psychosis, and how to develop novel psychological treatments that complement the neuropharmacology enterprise. Recent approaches are well-positioned to give us a complementary perspective that takes the ‘mind’ as the major unit of function. Will the technology revolution enable digital assessment and phenotyping and more effective digitally supported treatments? |
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| 11:35AM-12:05PM | Discussion One lead by Brenda Bloodgood | |
| 12:05PM-1:30PM | Break for Lunch |
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| 1:30PM-2:00PM | Discussion Two lead by Gerard Sanacora | |
| The discussion leaders will give brief remarks to kick off the discussion – the discussion leader will then manage the group discussion nudging it in challenging directions. | ||
| 2:05PM | Session Two - Chair, Peter Cannoll |
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| 2:05PM-3:20PM | Rapid talks that introduce new or provovcative ideas and tools | |
| Evelina Fedorenko (2:05PM-2:30PM) | ||
| Raag Airan (2:30PM-2:55PM) | ||
| Kaf Dzirasa (2:55PM-3:20PM) | ||
| 3:20PM-3:50PM | Discussion | |
| 3:50PM | The remainder of the afternoon is dedicated to
the breakout groups. Groups will be given specific charges –
but the goal is for them to create their version of the new
framework. |
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| 6:30PM-7:30PM | Reception, Garden Room | |
| 7:30PM-9:30PM | Dinner in the Mansion | |
| Date & Time | Event | |
|---|---|---|
| 7:00AM-8:30AM | Breakfast in the Mansion | |
| Workshop continues, New York Room | ||
| 9:00AM | Session Three - Chair, Susan
Fitzpatrick |
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| 9:00AM-10:30AM | Breakout groups continue discussions | |
| 10:45AM-12:00PM | Reports from breakout groups and discussion | |
| 12:00PM-12:30PM | Closing Synthesis Michael Halassa |
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| 12:30PM | Lunch in the Mansion& Departures (Please schedule departing flights for no earlier than 3:00PM) | |
